• Sun. Apr 14th, 2024

Scientists Create 6-Legged Mouse Embryo with Extra Hind Legs instead of External Genitalia through Gene Manipulation: Implications for Development and Disease

BySamantha Nguyen

Apr 3, 2024
Creating a six-legged mouse for the first time

In Portugal, researchers have developed a 6-legged mouse embryo with an extra pair of hind legs instead of external genitalia. The study was led by Moisés Mallo, a biologist at the Gulbenkian Institute of Sciences in Oerias, Portugal. The team aimed to investigate the effects of Tgfbr1 on spinal cord development.

The Tgfbr1 gene codes for a protein called transforming growth factor beta type 1 receptor, which plays a role in cellular responses like cell growth and division. Mutations in this gene can increase the risk of skin cancer. The researchers stopped the activity of the Tgfbr1 gene in mouse embryos during pregnancy and found that it led to the development of hind legs instead of external genitalia.

Tgfbr1 dictates whether structures develop into genitals or legs. This means that inactivating the protein can alter the activity of other genes, resulting in mice with extra legs and no external genitalia. The research team plans to investigate how Tgfbr1 and related genes affect other systems, such as cancer metastasis, and whether similar processes occur in reptiles with double penises.

The embryos used in the study were collected from mice aged 3-6 months. The research team dissected the embryos and analyzed them further without distinguishing between male and female embryos since their external genitalia do not differ.

Further research will focus on understanding the broader implications of the Tgfbr1 gene in development and disease.

In conclusion, scientists have successfully created a 6-legged mouse embryo with an extra pair of hind legs instead of external genitalia through genetic manipulation. This study has opened up new avenues for research into spinal cord development and its impact on other systems such as cancer metastasis.

Mallo’s team discovered that Tgfbr1 dictates whether structures develop into genitals or legs by controlling gene expression patterns during embryonic development. They also found that mutations in this gene can lead to increased susceptibility to skin cancer due to disrupted cellular responses.

This study has important implications for our understanding of genetic disorders associated with spinal cord abnormalities such as hydrocephalus (fluid accumulation) or neural tube closure defects (failure of neural tube closure). It could also pave the way for future studies on regenerative medicine approaches to treat these conditions by using stem cells or other types of cells modified to express specific genes.

Overall, this is an exciting discovery that could lead to significant advancements in our understanding of human disease mechanisms and potential treatments based on molecular targets identified by genetic studies like this one.

By Samantha Nguyen

As a content writer at newsskio.com, I weave words to craft compelling narratives that captivate readers and bring stories to life. With a keen eye for detail and a passion for storytelling, I strive to create engaging and informative content that resonates with our audience. Whether I'm delving into the latest news trends or exploring unique angles on various topics, my goal is to deliver quality content that informs, entertains, and inspires. Join me on this journey as we uncover the news stories that matter most.

Leave a Reply